For example, with a slight modification of ligands, Al compounds have been tuned from highly isospecific (Pm = 0.79) to highly heterotactic (Pr = 0.96) in ROP of rac-LA.
By judicious design and choice of metal nodes and bridging ligands specific framework topologies can be targeted, while functionalisation and modification of the ligand and metal centers can fine-tune the electronic and chemical nature of the resultant framework surface.
Our work shows that the rational structure modification of ancillary ligand is an effective approach to develop deep blue-light-emitting materials.
It seems to be possible to adjust gently the coupling between the spins by synthetic modification of the ligand that opens a wide possibility for crystal engineering of magnetic chain systems.
Our results clearly indicate that agonism and antagonism of the antibody/cytokine receptor chimera can be readily switched by a subtle modification of the ligand binding domain as well as that of GPCRs, also implying the existence of inverse agonism in cytokine receptor superfamily.
It was found that control of the stereochemical preference between (S∗,S∗) and (S∗,R∗) diastereomers by substituent modification of the ligand sidearms was possible in the process of crystallization with the preferred coordination of the sidearms generally consistent with expectations based on the electron-donating or -withdrawing properties of the sidearm substituent groups.
The cell penetration efficiency of nanoparticles can be boosted by surface modification of targeted ligand, such as folate, RGD peptide or transferrin (Mi et al. 2011a, b, 2013; Zhao et al. 2012).
The observed differences can be explained by drastic modification of the ligand field states due to the fluoride binding.
We speculate that the lack of correlation could be due to modification of NKp30 ligand(s) in these cells, leading to their altered recognition by the fusion proteins.
The general structure is retained when part of the Ti atoms is replaced by two-valent atoms (Fe2+, Zn2+, Cd2+, Ca2+, Sr2+), but the lower charge of the second metal renders modification of the ligand sphere necessary.
