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They include modification of levels of metabolic hormones and growth factors, improvement of the anti-tumour immune system, promotion of antioxidant defence and DNA repair.
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Current technologies analyze the interplay between epigenetic events (e.g., whole-genome DNA methylation and histone acetylation, modifications of levels of mRNA, modifications of levels of regulatory microRNAs) and proteomic and metabolomic events, thus increasing the potential of identifying pivotal pathways whose perturbation functionally contributes ultimately in inducing toxicity and disease.
FAS inhibition did increase TCA metabolite levels, which suggests a pathway for modification of ATP levels other than manipulation of fatty acid oxidation, which may be part of an AMPK related mechanism of action for these agents.
From an evolutionary perspective, such similar temperature dependencies allow cells to adapt more rapidly to temperature changes, because they result in minimal perturbations of intracellular metabolite levels, thus circumventing the need for extensive modification of enzyme levels.
In all cases, only one of the duplicates was expressed at very high levels, suggesting that the gene duplication preceded the modification of expression levels.
FTI treatment induced p21waf1/CIP1 expression or a higher level of Bax expression in p53HRCaax cells, while no modification of protein levels was observed in Adp53wt transduced cells.
Modification of GSH levels had no impact upon the pharmacokinetics or hypoxia selectivity of 64Cu(ATSM).
Objectives: Evaluate the relation between the modification of AT levels from baseline and circuit survival during CCRT.
Modification of miR-485-5p miR-485-5p miR-485-5p mimic or inhibitor alevels senescence and cell cycle characteristics of MM-BMMSCs.
Interestingly, the modification of H3K27me3 levels did not affect the methylation of H3K4 and H3K9 (Additional file 3).
There is still up-regulation of TPS and modification of transcription levels via the Mediator complex [Additional file 3].
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