Sentence examples for modification of insulin from inspiring English sources
Our work also presents nitrosative modification of insulin signaling proteins as a novel therapeutic target for improving muscle IR following LPS exposure during endotoxin shock or obesity-linked metabolic endotoxemia.
Our work demonstrates that iNOS-mediated tyrosine nitration of IRS-1 is a key mechanism of skeletal muscle insulin resistance in endotoxemia, and presents nitrosative modification of insulin signaling proteins as a novel therapeutic target for combating muscle insulin resistance in inflammatory settings.
Similarly, uraemic mice have increased ROS production, modification of insulin signalling molecules by O-GlcNAc and become insulin-resistant and glucose-intolerant.
Long-acting insulin analogs (LAAs) have been developed by modification of insulin chain in order to improve pharmacokinetic properties and decrease the risk of hypoglycemia.
Subsequently, two more articles were published showing that O-GlcNAc modification of insulin receptor substrate 1 (IRS1) occurs in close proximity of tyrosine phosphorylation sites and affects the tyrosine phosphorylation dependent function of IRS1 [ 10, 11].
In these cells, urea induces ROS production, which increases modification of insulin signalling molecules by O-GlcNAc and reduces insulin-stimulated IRS (insulin receptor substrate), Akt phosphorylation and glucose transport.
Since 1996, genetic engineering has allowed modifications of insulin yielding to multiple modified insulins with different pharmacokinetic and/or pharmacodynamic properties.
Additional snacks or modifications of insulin for children with blood glucose levels <80 mg/dL should also be considered.
Also, those physiological modifications of insulin sensitivity, as a consequence of insulin secretion, are different between males and females and are exacerbated by the obesity degree.
Tyrosine kinase is an enzyme responsible for structural modifications of insulin receptor substrate 1 during the events of the first cell cycle.
After analyzing data sent by patients, modifications of insulin basal rate and boluses were advised when necessary by heath care professionals; all exchanged messages were automatically registered by the DIABTel System.
