Sentence examples for modification of genomic from inspiring English sources
Recently, new technologies that use customized nucleases to facilitate targeted modification of genomic DNA have energized the field of genome engineering (Gaj et al. 2013).
Complete bisulfite modification of genomic DNA results in methylation-dependent genome-wide alterations in DNA sequences.
It is believed that this post-replication modification of genomic DNA provides a link between genomes and environment and may result in a phenotypic change that is heritable, but does not involve DNA mutation [ 5, 6].
Genetically modified (GM) crops are crops in which there is modification of genomic DNA by the use of genetic engineering techniques.
In such cases, the reduced specificity of the CRISPR Cas9 system, which may lead to the modification of genomic sites that are not identical to the sgRNA, can be harnessed for the simultaneous knockout of multiple homologous genes.
Here, we also examined whether the oxidative modification of genomic DNA was affected by oxygen exposure in the skin.
Bisulfite modification of genomic DNA was carried out by using EZ DNA methylation kit (Zymo Research, Orange, CA) according to the manufacturer's instructions.
DNA methylation is one of the most phylogenetically widespread epigenetic modifications of genomic DNA.
It is now established that the key mediators of the cancer cell phenotype are single base mutations, copy number alterations, translocations/rearrangements and epigenetic modifications of genomic DNA.
Progress in epigenomics has shown that the genome is regulated by a multifaceted and highly degenerate system involving families of transcription factors interacting with various chemical modifications of genomic DNA or its packaging proteins.
Chromatin structure and epigenetic modifications of genomic structure have been documented to regulate gene expression and affect replication, recombination and DNA repair [ 6, 7] through various mechanisms including nucleosome positioning and occupancy, histone modification (mainly acetylation and methylation) and DNA cytosine methylation [ 8, 9].
