As Kant makes the point in the Transcendental Aesthetic: "Not only are the drops of rain mere appearances, but...even their round shape, and even the space in which they fall, are nothing in themselves, but merely modifications of fundamental forms of our sensible intuition, and...the transcendental object remains unknown to us" (Kant 1973, 85).
Exploring versatile strategies for microstructural evolution and surface modification are of fundamental importance in the development of advanced electrode materials.
In a learning study involving training with speech stimuli, psychophysiological measures showed concommitant modification of the fundamental following response in the rostral brain stem [43].
In both cases, myosin performance divergence from native βMys occurs with minimal or no change in Vmax suggesting (for the case of the natural activator) that modification of the fundamental catalytic activity is impossible or counterproductive.
The data presented in this study show that these alterations are not restricted : i) to only the transcriptional step of ribosomal biogenesis and ii) to the early steps of tumor formation but that important modifications of this fundamental biological process also take place at later stages of tumor evolution, i.e. during the acquisition of the aggressive tumor phenotype.
Therefore, special modifications of the fundamental geometry of radial waveguides had to be performed to avoid the propagation of the unwanted higher order modes.
The complex and subtle modifications of the fundamental sound wave, also called harmonics, provide the acoustic characteristics to the sounds in order to make them intelligible, that is, to become phonemes or speech sounds.
The surface modification of graphene is of fundamental importance when working on the fabrication of high performing polymeric nanocomposite exploiting the exciting properties of this carbon-based material.
Thus, plant post-translational modification by SUMOylation is of fundamental importance in modulating numerous signaling pathways.
As the organization and packaging of eukaryotic DNA is achieved through the addition of core histones H2A, H2B, H3, and H4, which form the chromatin, the modification of core histones is of fundamental importance to conformational changes in chromatin.
