Sentence examples for modification of endogenous from inspiring English sources
Furthermore, pinpoint modification of endogenous plant genes is also an attractive method in molecular plant breeding.
This review evaluates the evidence for acyl glucuronide-derived perturbation of homeostasis, particularly that which might result from the covalent modification of endogenous proteins and other macromolecules.
In summary, though acyl glucuronide-derived covalent modification of endogenous macromolecules is well-defined, the work ahead needs to provide detailed links between such modification and its possible biological consequences.
The key question proposed by researchers, and now the pharmaceutical industry, is: does or can the covalent modification of endogenous proteins, mediated by reactive acyl glucuronide metabolites, lead to adverse drug reactions, perhaps idiosyncratic in nature?
The genomic modification of endogenous genes encoding TrpEP290S, AroF-1P148L, and PheAT310I, and the deletion of pykA improved phenol production 17-fold, while also minimizing the burden caused by plasmids and auxotrophies.
Future CAR T cell therapies could benefit from combined modification of endogenous TCR genes, histocompatibility genes, and components of signalling pathways.
Kimura, H., Hayashi-Takanaka, Y., Stasevich, T. J. & Sato, Y. Visualizing posttranslational and epigenetic modifications of endogenous proteins in vivo.
While multiple strategies to enhance plant carbon fixation have been suggested, and partially implemented, most of them are restricted to relatively simple modifications of endogenous metabolism, i.e., "low hanging fruit".
To determine the cellular modifications of endogenous Nm23-H1 and -H2 by oxidative stress, cellular Nm23-H1 was co-purified with Nm23-H2 by immunoprecipitation using Nm23-H1 antibody (Figure 1A) and various PTMs were analyzed using nanoAcquity™ UPLC™/ESI/q-TOF tandem MS as described in methodology.
We have tried from an early phase of this research to detect interactions and modifications of endogenous proteins.
36 Besides modifications of endogenous steroid profiles, other anabolic androgenic steroids such as 19-nortestosterone (nandrolone) and boldenone could be produced by microorganisms in urine matrix.
