Sentence examples for modification of downstream from inspiring English sources

The distribution of 90Y radioembolization within the tumor can only be partially controlled by the treating physician, i.e., by careful microcatheter placement and through modification of downstream fluid dynamics.

Moreover, post-translational modification of downstream proteins such as phosphorylation of Chk1 and Chk2 are essential for functional capacity of pathways.

CCCH proteins have been found to regulate post-transcriptional modification of downstream target pre-mRNAs [ 30, 31], interacting with different proteins (e.g. GhZFP1) [ 9], or transcriptionally activating/repressing target genes (e.g. AtHUA1, AtPEI & OsLIC1) [ 8, 12, 32].

Hence, alteration of the constituent elements of ECM can result in modification of downstream transcriptional responses of various cytokines and bring about changes in proliferation, survival, and migration which account for the findings in disease (Russo et al, 2005; Newby, 2006; Daley et al, 2008).

The reduction in both dopamine levels and D1 receptor expression might have caused a compensatory modification of the downstream signaling.

Our work therefore suggests a potential mechanism by which the post-translational O-GlcNAc modification of proteins downstream of the insulin pathway could differentially modulate insulin-mediated signaling outcomes.

Drug treatment appeared to delay recruitment as evidenced by the reduction in the heavy polysome peak (≥ 6 ribosomes: compare Figure 1B and 1C), and this effect was correlated with a modification of the downstream signalling targets of mTOR, including 4E-BP1 and S6 kinase.

During tumor progression, a variety of oncogenic signaling pathways induce modifications of the downstream effectors of key biological functions [ 76].

Jab1 also interacts with many components of known cell signaling pathways in the context of both phosphorylation and proteasomal activities, typically resulting in translocation of Jab1 to the nucleus and modification of activity in downstream pathways.

It is not known whether a stepwise chain of epigenetic events occurs during hypoxia, ie changes in DNA methylation occurring before histone modifications and alteration in expression of downstream mi-RNAs.

One hypothesis is that CRFR1-coupled Gβγ subunits have a unique molecular property (i.e. post-translational modification) that facilitates activation of downstream signaling pathways.