Inhibition of the mevalonate pathway by lovastatin suppresses the synthesis of two substrates that provide the isoprenoid moieties for post-translational modifications of diverse proteins: farnesyl and geranylgeranyl diphosphates [ 33].
The method is widely accepted and has been subject to modifications of diverse visual and model related features (see Khatri and Draghici, 2005, for an overview), though the basic statistical principle remained unchanged.
Previous work has shown that these enzymes may be involved in synthesis or modification of such diverse metabolites as alkaloids, terpenoids and phenolics, with ecophysiological roles in minimizing cuticular water loss, defending against herbivory, and attracting pollinators (reviewed in [ 2]).
Nucleosomes are highly dynamic and, through various core histone post-translational modifications and incorporation of diverse histone variants, can serve as epigenetic marks to control processes such as gene expression and recombination.
Recently, methylation has emerged as a prominent posttranslational modification of proteins regulating diverse cellular signaling pathways that influence cell survival, growth, and proliferation.
In effect, epigenetic modification facilitates the differentiation of diverse cell types from static genomic DNA.
Fish median fins are good examples of diverse modifications of external morphology for reproduction.
It can therefore be applied with appropriate modifications to the genomes of diverse plants species, especially large crop genomes that will be interesting to sequence in the future.
In addition, the generality of the solid-phase synthetic methodology should facilitate the construction of other sulfopeptide and sulfoprotein libraries to interrogate the importance of Tyr sulfate modifications in a number of diverse systems, including chemokine-chemokine receptor interactions (e.g. CCR5/RANTES), decoy receptors, and complement proteins, in the future.
Monoubiquitination is recognized as a reversible post-translational modification involved in the regulation of diverse processes such as membrane transport, transcription and signal transduction [ 37, 38].
