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A few studies have examined the effect modification of diabetes and endometrial cancer by body weight.
The authors point out that the major diabetes prevention trials to date have focused on modification of diabetes risk factors on the individual level.
Alternatively, lifestyle factors that were unaccounted for in this study may mediate the change in triglyceride and/or the associated modification of diabetes risk.
Future studies should focus on modification of diabetes management skills in adult patients with type 1 diabetes who have suboptimal glycemic control.
The goal of medical management was the modification of diabetes medications until the patient reached the therapeutic goal of a glycated hemoglobin level of less than 6.0% [ 14] or 7% [ 15] or became intolerant to the medical treatment.
In terms of primary care for example, modification of diabetes screening methods or screening for diabetes patients at high risk for other diseases could be steps in the direction of improving HRQOL.
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Future trials in this field should take into account a modification effect of diabetes.
We also assessed effect modification by a history of diabetes (diabetic vs. non-diabetic) and by the four possible combinations of obesity and history of diabetes (diabetic and obese, diabetic and non-obese, non-diabetic and obese, and non-diabetic and non-obese).
Additional secondary endpoints are the changes of the scores of two questionnaires: (1) a diabetes-specific quality of life questionnaire, which is a modification of the diabetes quality of life questionnaire used in the DCCT [ 45].
Diabetes was defined if one of following existed: current use of antidiabetic agents, diet modifications because of diabetes, fasting glucose ≥7.0 mmol/l (126 mg/dl), or 2-h postprandial glucose ≥11.1 mmol/l (200 mg/dl).
The possible effect modification of type of diabetes on the associations was studied.
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