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Cardiovascular implant-associated complications such as infection and thrombosis may be reduced by modification of device surfaces using antimicrobial and antithrombotic agents.
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This study proved that CFD research can test modification of devices, and provide information which could not be obtained by experiment.
However, balancing the risk of bleeding with the antithrombotic efficacy of these drugs continues to be a challenge, and surface modification of devices with these drug molecules to mitigate device thrombosis locally has been explored.
The program's other options included physical interdiction of devices like laptops to install snooping devices — but there have been security advances like hardware encryption in recent iPhone models that would make modification of devices much more difficult.
Among the promising approaches to combat biofilm infections is the generation of surface modification of devices to reduce microbial attachment and biofilm development as well as incorporation of antimicrobial agents to prevent colonization.
This paper discusses these effects and shows how this problem could be successfully addressed with minimal modifications of device layout.
In addition, if the modification of the device is small, leaving the modified device practically equivalent to the original one, no clinical data or re-assessment is necessary for approval.
Since bacterial colonization of the implant is a prelude to clinical infection, antimicrobial modification of the devices may inhibit device colonization and subsequent infection.
Modification of the device allows combined epicardial-transthoracic defibrillation.
Apple's mobile operating system, iOS, does not usually allow apps to monitor each other, so the information was gathered from users of "jailbroken" iPhones, on which Apple's usual controls have been disabled to allow modification of the device and installation of apps not offered through Apple's App Store.
The modification of medical device surface with adhesive ligands has been recently shown to be an effective means for making a bioselective surface which can inhibit bacterial adhesion while promoting host cell adhesion on device materials.
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