Sentence examples for modification of compounds from inspiring English sources

Fungal cultures have been widely used for the structural modification of compounds to afford structurally novel derivatives [1, 2], while utilization of plant cell suspension cultures for structural transformations is comparatively a new approach [3].

As for the selectivity towards PDE10A, it could be improved by analog modification of compound 8, which favors the hydrogen bonding with Tyr683 in the PDE10A selectivity pocket.

In general, structural modification of compound 2 either to nitrate ester or oxime hybrids showed better anti-inflammatory with less ulcerogenic liability than their corresponding starting intermediates.

We identified that the structural modification of compound 19 by attachment of a bulky group on pyrrole ring along with an electronegative group on quinazoline ring and a hydrogen-bond donor on methyl formate opens a new avenue towards the optimization of novel chemical entities to develop potent inhibitors for EGFR autophosphorylation.

Further modification of compound 5 c also focused attention on the amino group.

Another strategy involves chemical modifications of compounds in order to confer upon them some capacity to cross CNS barriers.

Such approaches [13] may involve "retargeting" via modification of known compounds, or simply "repurposing" known compounds to new applications when target profiles are suitable.

Subsequently, Bushakra et al. used the S1×L linkage map to identify compounds relating to the modification of cyanadin compounds in Rubus.

Within the sphere of cancer, a number of important new commercialized drugs have been obtained from natural sources either by structural modification of natural compounds or by the synthesis of new compounds using natural compound as model.

Within the sphere of cancer, a number of important new commercialized drugs have been obtained from natural sources, by structural modification of natural compounds, or by the synthesis of new compounds, designed following a natural compound as model [ 8].

Future analysis and modification of our compounds will advance insight into the colchicine site-drug interaction and promise to result in new anticancer compounds with optimal performance and, possibly, minimal toxicity.