Sentence examples for modification of compound from inspiring English sources
As for the selectivity towards PDE10A, it could be improved by analog modification of compound 8, which favors the hydrogen bonding with Tyr683 in the PDE10A selectivity pocket.
In general, structural modification of compound 2 either to nitrate ester or oxime hybrids showed better anti-inflammatory with less ulcerogenic liability than their corresponding starting intermediates.
We identified that the structural modification of compound 19 by attachment of a bulky group on pyrrole ring along with an electronegative group on quinazoline ring and a hydrogen-bond donor on methyl formate opens a new avenue towards the optimization of novel chemical entities to develop potent inhibitors for EGFR autophosphorylation.
Further modification of compound 5 c also focused attention on the amino group.
Fungal cultures have been widely used for the structural modification of compounds to afford structurally novel derivatives [1, 2], while utilization of plant cell suspension cultures for structural transformations is comparatively a new approach [3].
In order to investigated whether the observed modification products of compound 10, namely P1, which according to the previous results represents compound 15, and the two unknown compounds P2 and P3, are potent to inhibit ASKs, we purified the products by solid phase extraction and two fractionations by HPLC.
Another strategy involves chemical modifications of compounds in order to confer upon them some capacity to cross CNS barriers.
Furthermore, we will describe how information about the region of a compound that triggers a toxicity alert can be interactively visualised to guide the modification of a compound to reduce the likelihood of toxicity.
Pyrroloazepinones 8a j and 9a j were designed by structural modification of lead compound 3.
In combination with heat map coloring, linear support vector machine models can help to guide the modification of a compound in later stages of drug discovery.
Thus, we conclude that our method can help to guide the modification of a compound in later stages of drug discovery.
