Sentence examples for modification of cholesterol from inspiring English sources
Growth cone collapse induced by genetic (npc1−/−) or pharmacological modification of cholesterol metabolism was Rho kinase (ROCK -dependent and associated with incROCK -dependenttein synthesis; both processes were significandly reduced by P38 Massociated2 inhibition.
10.7554/eLife.07999.006 Figure 3. Modification of cholesterol biosynthesis rate.
Numerous studies have reported that modification of cholesterol content can affect APP processing.
In particular, it is not clear whether the modification of cholesterol homeostasis in AD brains is a cause or a consequence of the disease.
To investigate whether this control of neuronal activity by APP was related to modification of cholesterol turnover, calcium oscillations were analysed in neurons treated by mevastatin, an inhibitor of HMGCR.
Of note, whereas abnormalities in cholesterol metabolism are tied to a derangement of cholesterol synthesis and uptake in the peripheral tissues, leading to increased 'total' plasma cholesterol, that is, hypercholesterolemia, in many cases, they also appear to involve oxidative modification of cholesterol and/or altered cholesterol homeostasis within the brain.
The modifications of cholesterol metabolism associated with aging are ill-defined.
We suggest that modification of cellular cholesterol content with Dynasore protects cells against the effects of CDCs.
The modification of membrane cholesterol can be mainly performed by methyl-beta-cyclodextrin (M βCD), statin and filipin.
The protective effect of Dynasore was also observed using a different toxin (SLO) and the stable HeLa cell line, suggesting that modification of cellular cholesterol content with Dynasore is a valid approach to protect against the effect of bacterial CDCs.
It has been recently reported that a modification of hepatic cholesterol metabolism, especially an impairment of the scavenger receptor class B type 1 (SR-B1 -mediated SR-B1 -mediatederived CE, might be reSR-B1 -mediatedlevated plasma HDL cholesterol concentrations [8].
