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Jindra, P. T., Tripathi, S., Tian, C., Iacomini, J. & Bagley, J. Tolerance to MHC class II disparate allografts through genetic modification of bone marrow.
It was found that the surface modification of bone char with nano-gold has various advantages such as high operating dynamic adsorption capacity and low cost preparation.
This study strengthened our understanding of interaction between protein and CaP and can be applied to surface modification of bone substitutes in granular shapes for the promotion of bone regeneration.
Thus both surfaces studied could be used for modification of bone implants (bone-anchoring parts of joint prostheses or bone replacements) in order to improve their integration with the surrounding bone tissue, for which improved cell substrate adhesion is also needed.
Genetic modification of bone marrow aspirates is a promising avenue of translational research to treat cartilage defects in patients especially using clinically adapted therapeutic rAAV vectors.
Therapeutic gene-based modification of bone marrow aspirates prior to re-implantation in sites of injury may enhance the chondroreparative processes to promote the formation of an improved cartilage repair tissue (Cucchiarini et al. 2014; Frisch & Cucchiarini 2016).
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In addition to the repeated radiological exposure to adolescents, DXA provides a selective estimation of bone mineral density on the basis of a two dimensional measurement dependent on the bone surface area; a finding largely influenced by the physiological modifications of bone geometry occurring during growth [28].
The Look AHEAD (Action in Health for Diabetes) Trial presents a unique opportunity to examine the longitudinal impact of lifestyle modification on bone mass in a large cohort of overweight and obese subjects with type 2 diabetes.
Significant attention has been devoted to the isolation, culture, and genetic modification of human bone marrow derived mesenchymal stem cells, because they generate cells of cartilage, bone, adipose, marrow stroma, and possibly muscle.
If this observation is proven to be true, it would suggest that modification of the bone microenvironment caused by PDB results in the delayed progression of prostate cancer to bone metastasis.
Endowing bone biomaterials with favorable osteoimmunomodulatory properties can be a highly valuable strategy for the development or modification of advanced bone biomaterials.
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