Sentence examples for modification of biomolecules from inspiring English sources
The quadricyclane ligation joins a small but growing list of tools for the selective covalent modification of biomolecules.
Bioconjugation, defined as chemical modification of biomolecules, is widely employed in biological and biophysical studies.
Inhaled environmental stressors damage the airways and lung parenchyma, producing irritation, recruitment of inflammatory cells, and oxidative modification of biomolecules.
The above reactions, as well as several newcomers with bioorthogonal attributes, have enabled the high-precision chemical modification of biomolecules in vitro, as well as real-time visualization of molecules and processes in cells and live organisms.
In summary, HYNIC represents a well-established way to exploit the highly reactive hydrazine group, to generate bioconjugate chemistry with a degree of bioorthogonality offering the possibility for highly efficient and site specific modification of biomolecules for imaging.
The modification of biomolecules with mPEGs is denoted PEGylation, and mPEGs are usually activated for selective PEGylation of amino groups of biomolecules under mild conditions [1, 3, 6, 7].
On the whole, the modifications of biomolecules that are mediated by HOX are numerous and highly damaging, which makes these oxidants highly effective toxic defense molecules that can be exploited by the human immune system to fight off microbial infection.
Indeed, oxidative stress associated modifications of biomolecules are known hallmarks of the aging brain [ 11, 72] and it is expected that heavy ion radiation with its propensity to cause higher oxidative stress and increased damage to biomolecules could accelerate changes in brain commonly associated with aging.
Reactive oxygen and nitrogen species (ROS and RNS, respectively), which are generated as a byproduct of many biochemical processes or as a result of environmental oxidative stress, cause specific and both reversible (signaling) and irreversible (oxidative damage) oxidative modifications of biomolecules, including proteins, lipids and DNA.
Examples include CC bond formation, deprotection and functional group modification, degradation of biomolecules, and redox modulation.
Critical properties of inorganic nanoparticles, surface functionalisation (modification), uptake of biomolecules, the driving forces for delivery, and release of biomolecules will be reviewed systematically.
