Glycosylation is an important post-translational modification of many biologically relevant molecules.
It has been well known for a long time that glycosylation is a very significant posttranslational modification of many biologically important molecules and that aberrant glycosylation of glycan structures is a common feature of neoplastic transformation.
Molecular modification in structures of biologically active substances that occur naturally is one of the main strategies to enhance healthy biological effects, as well as to reduce eventual side effects [1 3].
Click chemistry has been widely used in conjugation due to its fast, highly specific, and efficient reaction, which allows selective modification and incorporation of biologically active molecules (such as cell adhesion and enzymatically degradable peptides) in specific sites, even in the presence of various functional groups and under physiological conditions.
The endoplasmic reticulum (ER), an essential intracellular organelle, is responsible for the synthesis, posttranslational modification, and delivery of biologically active proteins to their proper target sites within the cell and the extracellular milieu, as well as for Ca2+ homeostasis (Brostrom and Brostrom 2003; Schröder and Kaufman 2005).
Moreover, the aspergillide scaffold could lend itself to diverse structural modifications in projected syntheses of biologically active congeners.
Modification of CdSe/ZnS QDs with biologically relevant molecules provides for multipotent probes that can be used for cellular labeling, bioassays, and localized optical interrogation by means of fluorescence resonance energy transfer (FRET).
Surface modification of implantable biomaterials with biologically active functionalities, including antimicrobials, has wide potential for addressing implant-related design problems.
The methodology was tested and optimized using a mixture of 18 DNA adducts representing a range of biologically relevant modifications on all four bases and using DNA from liver tissue of mice exposed to the tobacco-specific nitrosamine 4- methylnitrosamino -1- 3-pyridyl -1-butanone 4- methylnitrosamino -1- 3-pyridyl -1-butanone 4- methylnitrosamino -1- 3-pyridyl -1-butanone 4- methylnitrosamino -1- 3-pyridyl -1-butanone 4- methylnitrosamino -1- 3-pyridyl -1-butanone 4- methylnitrosamino -1- 3-pyridyl -1-butanone 4- methylnitrosamino -1- 3-pyridyl -1-butanone
