Last, our studies demonstrate some of the difficulties in interpreting and predicting transcriptional responses based upon individual histone modifications; and thus, suggest that an examination of a set of modifications on a given target gene, as performed herein, will be more informative.
At the CPR PTM Resource, information on the tissue distribution of posttranslational modifications on a given protein is provided along with topological protein information imported from other sources.
To understand the flexibility of biological networks, we propose a novel approach to analyze time-dependent networks, based on the framework of network completion, which aims to make the minimum amount of modifications to a given network so that the resulting network is most consistent with the observed data.
Increased hybridization signals indicated an enrichment of a specific histone modification for a given CpG island locus (red signals in Figure 1A and 1B).
Despite the power of ChIP-Chip for mapping global patterns of histone modifications, the above-cited studies generally provide only a static picture of levels of modifications under a given set of conditions.
The modification of properties of a given catalyst, and hence its catalytic performance, may be attempted by employment of dopants (promoters).
Therefore, rather than yielding the absolute concentration of a modification in a given tissue, the data show directly the extent to which the analyzed tRNA set is modified.
Stratified pooled effect estimates were calculated and reported if there was evidence of effect measure modification by a given characteristic.
Through altering the degree of chromatin compaction, PTMs of histone tails create chromatin structures favorable either for activation or repression of genes, depending on the genomic context and the combination of modifications at a given site [ 2].
By controlling the reaction time or the molar ratio between the reactants, this synthetic strategy makes it possible to tune the extent of modification of PVA for a given molecular weight of grafts.
