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Re-examination of the heteronuclear multiple quantum coherence (HMQC) NMR spectra of the enzyme inhibitor mixture indicates that dual modes of single covalent modification occur with a ≥3:1 ratio of S-alkylation of Cys172 to N-alkylation of His102.
A combination of transcriptomics with phosphoproteomics showed that changes in gene expression and protein modification occur within seconds.
Epigenetic alterations such as aberrant methylation and histone modification occur far more frequently than genetic mutations in cancers and can significantly affect the efficacy of messenger RNA (mRNA) synthesis without changing the primary DNA sequence [ 2].
The majority of the sites of covalent modification occur at intrinsically unstructured linear peptide docking motifs that flank the DNA-binding domain of p53 which play a role in anchoring or in allosterically activating the enzymes that mediate covalent modification of p53.
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Moreover, whether the modification occurred can be determined as well as the extent of the modification.
Finally, phase transformation in a rutile polymorph modification occurs at temperatures above 815 °C (third step).
Glass surface modification occurred using Nd YAG laser irradiation in SF6 atmosphere.
Conversely, in the case of MO no TOC modification occurred during the catalysis.
However, whether this novel Rab1 modification occurs during bacterial infection of host cells was still unclear.
A large epigenetic modification occurred after the cryptophyte nuclei were sequestered into the ciliate.
Additionally, sagittal plane joint kinematics were evaluated to determine if any modification occurred.
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CEO of Professional Science Editing for Scientists @ prosciediting.com