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However, preliminary 2D-DIGE data obtained already at 1 h after a single exposure to UVB showed that some spots identified as TRIM29 had increased intensity compared to the control cells, suggesting that a post-translational modification might occur.
Instead, this modification might occur in tumor cells following the activation of a signal transduction pathway inducing tumorigenesis.
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Post-translational modifications, degradation and other chemical modifications might occur during the preparation process and even during storage (Roque et al., 2004; Cohen et al., 2007; Shukla et al., 2007).
These results suggested that epigenetic modifications might occur in these tumors.
This information suggested that dynamic epigenetic modifications might occur in genes associated with cancer, cell cycle regulation, and gut disease development in Apcmin/+ mice.
Even though there is no evidence for post translational modifications of murine WAP in the literature, this result suggested that post translational modifications might occur in SEG/Pas WAP.
In fact, posttranslational modifications might occur in mussel cells but this can hardly be investigated due to the low expression levels of MgCRP-I genes which, in turn, makes the purification of native peptides difficult.
Since randomizing patients to PET or non-PET groups is unethical, we decided to use a before-and-after design to evaluate any modification that might occur in the management of SPN diagnosis within participating regions.
In vitro models have been widely used to identify the specific functions of the endothelium and to understand the molecular modifications that might occur during angiogenesis.
In addition to improving coverage and confidence in protein identifications, the analysis of large MW fragments enables studies of multiple posttranslational modifications (PTMs) that might occur on a single protein molecule, such as glycosylation.
It has been proposed, that during ovarian cancer progression, modification of PELP1 expression might occur.
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