Suggestions(2)
Exact(3)
How epigenetic modification might cause the defects Dr Kimmins saw, she does not yet know.
The final three amino acids of RAB7A (Cys-Ser-Cys) were deleted to prevent C-terminal prenylation as such modification might cause high background in the assay.
MDM2-ARR binding is constitutive and does not persist after receptor activation, suggesting that ubiquitin modification might cause a conformational change on ARR required to promote internalization.
Similar(57)
A previous meta-analysis suggested that even small changes in BP caused by dietary modification might have a significant impact on the prevalence of hypertension5.
The protective effect of OEO might cause modification of selected intestinal microbiota, inhibition of inflammatory cytokine expression and subsequent increased occludin expression in jejunum by enhancement of antioxidative capacity.
However, during the third step of extend case transfer architecture, modifications of private work flows might cause some fatal problems, such as dead locks, live locks and dead tasks.
Large number of retrovirus infections might cause strong epigenetic modifications by the chromosomal integration of retroviruses, and the use of HDAC inhibitor might generate chromosomal instability (Sakurada 2010).
Alternatively, polymorphic variations in the primer binding sequence on the gene might cause allele-specific modifications of PCR efficiency leading to variable gene dosages.
Further studies could assess to what extent modifications in clinical practice and/or external interventions might cause changes in the patient mix.
Random mutagenesis or genetic modification of an organism without consideration of its consequences to the entire system might cause unwanted changes in cellular metabolism.
The present study detected a structural modification of the α3 subunit, suggesting that direct effects of HAMLET on this subunit might cause further disordering of the proteasome.
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