Sentence examples for modification mediated by from inspiring English sources
As carnosine has been shown to exert protective activity against protein modification mediated by MG and other reactive carbonyls, the dipeptide has been explored for its therapeutic potential towards complications associated with type-2 diabetes [99].
Internalizing EGFR requires c-Cbl and Lys63-linked polyubiquitin chain modification mediated by c-Cbl is essential for sorting activated receptors to the lysosomal degradation compartment [17], [18], [19].
Future studies on this and other eukaryotic fic domain-containing proteins and the identification of AMPylated substrates will provide insight into this novel posttranslational modification mediated by the fido domain-containing family of proteins.
The repression of both the BIM (BCL2L11A) and p16INK4A (CDKN2A) genes by EBNA3A and EBNA3C is marked by H3K27 trimethylation [11], [26], an epigenetic modification mediated by the polycomb complex PRC-2 [59], [59].
Acetylation of proteins is a post-translational modification mediated by specific acetyltransferases, using the donor acetyl CoA.
In this model, Shh directly induces Nmyc expression and indirectly affects Nmyc posttranslational modification, mediated by its indirect targets, cyclinB and possibly other cyclins [ 30, 44, 61].
Shi, Y. et al. Coordinated histone modifications mediated by a CtBP co-repressor complex.
Yu, Z. et al. Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila.
These results provide the first evidence of the role that TLR4 functions play in the behavioral consequences of alcohol-induced inflammatory damage and suggest that the epigenetic modifications mediated by TLR4 could contribute to short- or long-term alcohol-induced behavioral or cognitive dysfunctions.
Importantly, we did see repeatable and significant differences in glycolytic dependence associated with Ets-1 expression, and the lack of changes in protein expression could therefore be due to post-translational modifications mediated by Ets-1.
The intronic TE renders FLC subject to repressive chromatin modifications mediated by TE-derived siRNAs [ 42].
