While in some cases such alterations have little (or no) practical effects, there are situations in which the deviation of contact parameters from the original design is a primary source of malfunctioning and unexpected early failures; thus, the analysis of contact modifications may represent an indirect yet effective method for estimating wear effects.
Targeting Tat posttranslational modifications may represent a new and unique therapy for HIV-1 sufferers.
In this context, epigenetic modifications may represent accessible molecular markers of early-life events that may be more stable than direct measures of gene expression.
We observed no obvious property of their DNA-contacting residues that strongly predicts success or failure and hypothesize that requirement for ligand binding, dimerization, cofactors, or protein modifications may represent other potential explanations for failures in heterologous assays.
We conclude that a lack of hTRM9L, and possibly due to the inability of cells to modulate the levels mcmU and other tRNA modifications, may represent a deficiency in tumours that might be specifically exploited to induce killing of these tumour cells.
Application of a magnetic field is one of potential methods to align and orient template molecules in view of specific pore structures and adsorption modification and may represent a new route for porous structure design.
This study highlights the intriguing possibility that differential modification of cysteines may represent a general paradigm in cell signaling and, in this context, S-nitrosylation of PSD-95 may function to regulate the duration of NMDA signaling.
This work shows that modification of substrate stiffness may represent a method for regulating arterial-venous differentiation for the fulfilment of diverse functions of the vasculature.
Thus, modification of Wnt signaling may represent a therapeutic option in IPF.
Thus, genetic modification of stem cells may represent an important strategy in improving stem cell therapy.
