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Behaviourally mediated responses to landscape modification may generate behavioural divergence among populations along environmental gradients.
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The presence of NRPS also offers the possibility of genetic modifications which may generate peptides with high pharmacological activities.
Moreover, the presence of NRPS could offer further genetic modifications, which may generate novel genetically modified peptides in the future with high pharmacological importance.
A single-step modification may give higher overall functional density over a complicated two-step modification.
Therefore, this modification may give better representation for speech.
It has been proposed that post-translational modifications specific to one tissue may generate tissue specific functions for a given protein.
This fact probes that slight modifications on the drug's design may generate significant differences in the final antitumour activity by modifying the DNA drug adducts, performance of resistance mechanisms and all the factors that play a fundamental role in Pt complexes' cytotoxicity.
These modifications, in combination with reactive oxygen species (ROS), may generate DNA single or double-strand breaks, which in turn may lead to mutations, chromosomal aberrations, and microsatellite instability [6][7].
As highlighted by several recent studies, this approach may have limitations: (1) the primary tumour may not always be available; (2) as indicated above, several genetic changes may occur between the primary tumour and the corresponding metastases; and (3) genetic analyses performed on paraffin-embedded tissues may generate artefacts because of fragmentation and chemical modification of DNA.
The mechanisms by which SoB impacts behavior are likely to be varied but presumably modification of the epigenome during fetal development is a key pathway that may generate untoward consequences later in life.
Additionally, the loss of REST may generate small but reproducible effects in measured histone modifications due to local changes in nucleosome density, rather than actual changes in a specific modification (Zheng et al., 2009).
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