Sentence examples for modification marks in from inspiring English sources

Therefore, we investigated the intensities of the 20 histone modification marks in each fragment of the U- and M-CGIs and their flanking sequences.

The TFBSs enriched for 5hmCs were depleted for nascent transcripts and activating histone modification marks in human and mouse ESCs.

Myc has more target genes than any of the core factors, and its target genes show unique histone modification marks in their promoters.

ChIP-seq peaks of histone modification marks in NHEK cells were downloaded from the ENCODE website [ 29] and averaged in 50 bp windows surrounding the DMR sites.

The identification of DNA methylation and histone modification marks in immune function-related genes could encourage the development of new epigenetic-based post-transplant biomarkers that have direct applications in clinical practice (Table 1).

Finally, ChIP analyses of total histones and different histone acetylation and methylation marks have shown that T3 treatment leads to the removal of core histones at the T3 target genes, and a reduction in the levels of repression histone modification marks and an increase in the levels of activation histone modification marks in the remaining nucleosomes [ 31, 88, 89, 92].

There was less evidence for either histone modification mark in human mammary epithelial cells (HMEC; not shown).

Just recently there has been an indication that H2 BK120 Ac appears as an early modification mark in TSS regions and affects H2 BK120 Ub [ 57], a modification that regulates H3 K4 Me3 [ 58, 59], providing support for our finding.

It was shown that 5hmC is a major epigenetic modification mark in an adult human liver, playing an important role in hepatic gene expression changes in hepatocytes [ 46, 47].

This pattern of modification marks is in accordance with the activating and silencing effects associated with these histone modifications in other cell types [ 43, 44].

From the chromatin point of view, actively transcribed genes are characterised by Set2-mediated H3K36me2/3 and Dot1l-mediated H3K79me2 histone modification marks present in gene bodies (Nguyen & Zhang, 2011; Venkatesh et al, 2012).