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We also analyzed a genome-wide map of H3K4me3 and H3K27me3 from human sperm (Hammoud et al. 2009) and mouse testis (Cui et al. 2012), as well as H3K4me3 modification map from mouse testis and liver (Smagulova et al. 2011) generated by chromatin-immunoprecipitation sequencing methods.
Information on the presence of a given modification in RNA was essentially extracted from the RNA modification database [ 174], the tRNA database [ 4], the small rRNA modification database [ 3] and the 3D ribosomal modification map database [ 14] (for corresponding http, see above in Introduction section).
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A 12-year annual time series demonstrated the feasibility for land cover change and modification mapping.
(2009) provide snapshots of histone modification maps for two different stages of human blood cell development.
The compatibility of this enzymatic approach with liquid chromatography tandem mass spectrometry (LC MS/MS) RNA modification mapping was then demonstrated.
Genome-wide histone modification maps have now been generated for a number of eukaryotic organisms.
Computational methods have been developed to reveal histone code hidden in global histone modification maps.
Therefore, nucleosome maps by MNase-seq or ChIP-seq have higher or equal resolution compared to histone modification maps.
An alternative, and orthogonal, approach is to integrate individual histone modification maps to discover latent relationships between epigenetic marks.
We illustrate the use of DASMiner by creating integrative models of histone modification maps and protein-protein interaction networks.
The cells were digested with MNase to generate mainly mononucleosomes with minor fraction of dinucleosomes for histone modification mapping.
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