Due to these facts, the application of MS/MS techniques for identification of the modification location was unpractical.
Search output has information on essential components like CrisprID, organism, gene, target, modification, location and PMIDs (see Supplementary Figure S2).
To link to PRIDE's modification location table described below, a two-filter/attribute importable and exportable were defined using the shared UniProt and PSI-MOD IDs, while to link to the COSMICMart data set, the two-filter/attribute values were based on shared UniProt ID and modified/mutated residue position.
At the modification position, pol has a 4.4-kb insertion and cam has an 813-bp insertion, suggesting that pol was derived from cam at this location through evolutionary modifications resulting in a 813-bp sequence deletion and 4.4-kb sequence insertion.
For modeling complex biological processes intuitively, we are required to deal with various kinds of biological information, e.g. the density of molecules, the number of molecules, sequences, molecular modifications, binding location, localization of molecules, etc.
An employed bee generates the modification of location (solution) in its memory according to local information (visual information) and tests the nectar volume (fitness value) of a new food source (new solution).
Within the life of an animal the pathways are regulated by all the mechanisms by which the function of a gene product may be regulated: gene expression, post-translational modification, subcellular location, and so on.
We investigated the functional relationships between chromatin compaction, distribution of histone modifications and location of RNA polymerase II in intact murine rod photoreceptors using cryo-preparation methods, electron tomography and immunogold labeling.
One characteristic that is highly desired in transportation-related applications, and particularly journey planners, is transferability – i.e., the capacity to be used with minimal modification in different locations.
