Sentence examples for modification itself from inspiring English sources

Additionally, unintended effects of the genetic modification itself cannot be excluded, as direct or indirect consequences of insertional mutagenesis, creating possible unintended metabolic effects.

Importantly, the N6 variant was therapeutically efficacious even after a 50% reduction of viral dose, thereby indicating that transgene modification itself can improve the dose efficacy of HD-Ad.

This allowed us to follow in detail the potential healtheffects and their possible origins due to the direct or indirect consequences of thegenetic modification itself in the NK603 GM maize, or due to the R herbicide formulationused on the GM maize (and not G alone), or both.

If the latter is true, our observations would indicate that only the modified form of LYL1 is subjected to degradation with the modification itself acting as a signaling event.

This so-called "cultivar" effect includes both the influence of the natural genetic background of the 2 maize lines (i.e. MON810 and the conventional counterpart) and the possible impact of the genetic modification itself.

These include work on a putative Dnd-dependent restriction-modification system, the precise nature of the DNA modification itself, the core sequence motif that targets the site-specific modification in S. lividans [22], and the increasingly well characterized novel biochemical pathway that mediates this unique biological process.

To add to this complexity, IL-6, a major cytokine in the pathogenesis of RA, is known not only to be an NF-κB-inducible gene but also to initiate epigenetic modifications itself.

The trajectory modification records itself significant modifications.

Firstly, we compare the selected variation operators in pairs, each operator with a modification of itself, in which we remove those elements related to the Pareto efficiency.

For that reason, EU regulations need to be adapted to focus on the traits of the GM crops - such as their pest-resistance or enhanced yield - rather than on the genetic modification method itself, the scientists argued.

First, amino-terminal modifications of nascent peptides occur in nearly all proteins in both prokaryotes and eukaryotes, and the removal of the initiator Met, which occurs soon after the amino terminus of the growing polypeptide chain emerges from the ribosome, is not only an important amino-terminal modification in itself, but also required for further amino-terminal modifications.