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Epigenetic modification is reversible and DNA methyltransferase inhibitors may be efficacious in CIMP-positive cancers.
This modification is reversible, allowing for a dynamic measurement of the MAPK activity.
This modification is reversible, and ubiquitinated proteins can be proteolytically deubiquitinated by specific deubiquitinating enzymes [ 30, 31].
This modification is reversible and when the DNA repair is completed, the SUMO tags are removed and the repair complexes are disassembled.
This is in agreement with the results of a mass spectrometric analysis that was carried out by Masuda group, suggesting methylol modification is reversible by heating [ 18, 19].
The discovery that gene activity is highly correlated with the acetylation state of histones, and that this modification is reversible, has spurred intense efforts to understand the role of this modification in regulating gene expression (1).
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These modifications are reversible, but require less reducing power for nitrosylation than for glutathionylation.
Unlike genetic mutations that accumulate in cancer, epigenetic modifications are reversible [20].
The cytoskeletal modifications were reversible upon return to normal growth conditions (1 ×g).
It is therefore noteworthy that epigenetic modifications are reversible, which may make them an effective target for therapeutic intervention.
Epigenetic modifications are reversible modifications on the DNA of one cell or histones that may affect gene expression without altering the DNA sequence [ 100].
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