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These T cells recognize better gluten peptides that are deamidated, and this posttranslational modification is mediated by the enzyme transglutaminase 2 (TG2).
This post-translational modification is mediated by a family of three HIF-1α prolyl hydroxylases that use oxygen as a substrate such that enzymatic activity is tightly regulated by oxygen concentration.
Target site modification is mediated by erythromycin resistance methylase (erm) genes.
We show that Akt can phosphorylate the serine 134 residue of CSDA but, downstream of Bcr-Abl activity, this modification is mediated through the activation of MEK/p90 ribosomal S6 kinase (RSK) signaling.
Palmitoylation of the cytoplasmic tail of the CIMPR does facilitate its endosome-to-Golgi retrieval, but this modification is mediated by ZDHHC15, a palmitoyl transferase distinct from ZDHHC5 (McCormick et al., 2008).
This latter modification is mediated by ShhC, which shows similarity to intein domains and catalyses its own cleavage to form N-palmitoylated/ O-cholesterylated ShhN (19 kDa) (Fig. 1).
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We also conducted planned secondary analyses of whether effect modification was mediated by digoxin dose or by serum digoxin concentration.
The bands were absent when GFP-Smf1 was expressed in rsp5 mutant cells that have low levels of Rsp5 protein, suggesting that the modification was mediated by this enzyme.
The link between DNA methylation and histone modifications is mediated by a group of proteins with methyl-CpG-binding activity.
These modifications are mediated by small RNAs that are localized in CBs (scaRNAs) [14], [27] [30].
Arginine modifications are mediated by two classes of protein arginine methyltransferases (PRMTs), class I and II.
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