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This modification is linked with the electrochemical active surface area (ECSA) decreasing from 22 to 18 m2 g−18
Phosphorylation occurs at serine 10 of the H3 N-terminal tail, and the time course of H3 phosphorylation closely corresponds to the transient expression of activated immediate-early genes, suggesting that this histone modification is linked to transcriptional activation [reviewed in 37].
Although this modification is linked to pathogenesis, the precise mechanisms involved have not yet been elucidated.
The H3K36me3 modification is linked to transcriptional elongation (Krogan et al., 2003).
On the other hand, we analyzed the number of remodelers to which each histone modification is linked.
Notably, some epidemiology textbooks [ 5] reserve the term effect modification for when the modification is linked to a causal mechanism and use the reduced term modification otherwise.
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Of note, the magnitude of effect modification was linked to number and not to type of HFE variant alleles.
It has previously been shown that eIF5A and the DHS-mediated hypusine modification are linked to cancer (Guan et al., 2001; Preukschas et al., 2012; Tang et al., 2010; Zender et al., 2008).
Fraga et al (2005a) found that loss of monoacetylated lysine 16 and trimethylated lysine 20 forms of histone H4 is a global hallmark of human cancers, and in prostate cancer, global patterns of histone modification are linked to the risk of prostate cancer recurrence (Seligson et al, 2005).
Fig. 3 Aberrant epigenetic modifications are linked to alterations in the autophagy pathway in critically ill patient osteoclasts.
But as it cleaves the peptide backbone, trypsin also destroys any chance researchers have of understanding how posttranslation modifications are linked.
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