Exact(11)
Such a modification is likely to be necessary for in vivo kinase substrate labeling experiments where competitive phosphodonors are present in high concentrations.
Additionally, this modification is likely to be unique to K19 since sequence comparison of human K19 to other type I human keratins shows a lack of conservation for Tyr391.
Although the precise nature of the putative ROS modification of NIX and/or Mieap has not been identified, we hypothesize that the ROS-regulated modification is likely to play a crucial role in the interaction of Mieap and NIX, which allows Mieap to distinguish healthy mitochondria from unhealthy mitochondria.
Even though lifestyle modification is likely to affect the incidence of diabetes and cardiovascular disease, the effectiveness of lifestyle interventions probably differs over patient groups.
In this context, we should mention that the modification is likely to improve resistance against phosphodiesterases, as has been shown for the 2′-OCF3 counterparts.
The estimated 1 10% modification for the other sites is a lower limit as the modification is likely to decrease the ionization potential of the respective peptides.
Similar(49)
Similarly systematic chemical names, prior to modification, are likely to be resolvable by chemical name to structure algorithms.
Nevertheless, molecular species differing solely from a post-translational modification are likely to behave similarly.
The functional consequences of such modification are likely to depend upon the nature, concentration, and exposure time of the oxidizing agent; the type of chemical modification; and the specific cysteine residues that are affected.
Note that any of those modifications is likely to reduce the QoS level in the neighboring cell.
The public health impact of such lifestyle modifications is likely to be greatest in ethnic groups, such as Hispanics, with a consistently high prevalence of obesity, diabetes, and the highest prevalence of sedentary behavior.
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