One potentially unstable modification is highlighted in Figure 4.
The importance of this modification is highlighted by the observations that whereas the Kar2_C63A mutation fully covers the kar2 deficiency under normal conditions, the mutant is impaired in growth under the very conditions associated with enhanced rates of oxidative modification of C63.
The versatility in structural modification is highlighted, and that it offers an effective avenue to access chiral ligands of diverse electronic and steric properties for optimization in various catalytic asymmetric transformations.
The power of ZFNs as genome modification reagents is highlighted by several publications in which engineered ZFNs were used to target homologous integration at native sites in the human genome [ 20- 24].
This transformation inevitably leads to a modification in the microstructure, which is highlighted by various parameters such as variations in specific surface area and pore size distribution.
Impact of modifications on topology, binding and aggregation is highlighted.
Multicomponent interventions combining diet, physical activity and behavioural modification have been highlighted as essential for weight loss and goal achievement, 2 with a comprehensive behavioural approach producing a 10.7 kg (11%) weight loss while significantly reducing attrition.
The proposed experiment is appropriately designed, although several small modifications should be highlighted: 1) Protocol 1, procedure points 5-6 do not reflect the original protocol and should be indicated by an asterisk.
The significance of a diagnosis of PAD, in terms of associated increased cardiovascular risk and the necessary risk factor modification, needs to be highlighted.
By default, proteins involved in chromatin modification (Kouzarides, 2007) are highlighted with a white border, which reflects the focus of our research team, but the user may accentuate any preferred group of proteins in this way.
The different operating conditions used to prepare the modified electrode, i. e. the initial concentrations of catalyst and Nafion® and the sonication time, were optimized and the modification of the electrode was highlighted by cyclic voltammetry and electronic scanning microscopy coupled with energy dispersive spectroscopy analysis.
