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Lifestyle modification is fundamental to obesity treatment, but few studies have described the effects of structured lifestyle programmes specifically in bariatric patients.
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Epigenetic regulation, including DNA methylation and histone modifications, is fundamental to tissue- and/or cell-type specific gene expression (Golob et al., 2008; Ikegami et al., 2009; Lieb et al., 2006; Shiota et al., 2004).
Recently, several studies have shown that silence of tumor suppressor genes by epigenetic modification is a fundamental mechanism for inactivation of cancer-related genes in the pathogenesis of human cancer [ 1].
The modification of synaptic thresholds is fundamental to neuronal adaptation paradigms.
Cholesterol modification of Hh ligands is fundamental for Hh activity and its modulation by Ptc; cholesterol biosynthesis is also required for intracellular Hh signaling transduction.
The knowledge of H2A modifications is still very limited, and the characterisation of novel histone markers is fundamental to understand how post-translational modifications can regulate gene expression.
"It is fundamental".
The fun is fundamental.
Contraception is fundamental health care.
"Work is fundamental for dignity.
The basic is fundamental.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com