Dose reductions and/or modification were frequently required in all three studies, whereas in the POCHER trial an amendment with doses reduction was mandatory for the continuation and completion of the study.
As described in previous studies, a correlation between local DNA methylation and histone modifications is frequently observed in epigenetic-mediated gene silencing [ 46, 47].
This is not always the case, and in exact treatments of these equilibria two modifications are frequently necessary.
Alternative splicing and posttranslational modifications are frequently used to tune the IDP functionality.
Moreover, in cancer, aberrant epigenetic modifications are frequently found to be responsible for the silencing of tumor suppressor genes.
Altered DNA methylation, microRNA expression, histone, and chromatin modifications are frequently noted in meningiomas bearing prognostic and therapeutic relevance.
Furthermore, multiple intra-nucleosomal or inter-nucleosomal histone modifications are frequently observed within the same genomic loci.
Signaling sequences and sites of posttranslational modifications are frequently, or very likely most often, located within regions of intrinsic disorder.
Given that the changes of major metabolites and histone modifications are frequently observed in cancers (Katada et al. 2012), it is very important to understand the interaction between nutrient pathways and epigenetics in regulation of biological processes.
Dosing modifications were frequently used to manage AEs, with 80% of patients having temporary treatment discontinuations and/or dose reductions of one or both study drugs due to AEs.
In total, the number of infusion lines [ 10, 16], MV [ 7, 9, 14] (change of ventilator or ventilation settings), and sedation [ 9, 10] (initiation, maintenance, modifications) are frequently identified as equipment-related RFs.
