Sentence examples for modification in the level from inspiring English sources

Altogether, our MSAP analysis suggests modification in the level of cytosine methylation and alterations in DNA methylation patterns, particularly de-methylation, during in vitro culture.

We have additionally evaluated whether the effect of aspirin and NS-398 treatments on the sensitivity of Caco-2 cells to anticancer drugs correlate with any modification in the level of the bcl-2 family protein, one of the key regulator factors in apoptosis (Yang et al, 1995; Korsmeyer 1999).

Treatment for 7 days with 17β-HSD3 inhibitoRM-532-10505 by s.c. injection or oral gavage exerted no effect on the testis, prostate and seminal vesicle weight and no modification in the levels of plasma steroids.

In agreement, metabolic pathways of progesterone are affected by modifications in the level of gonadal hormones and by pathology or injury with a regional specificity and in a sex-dimorphic way.

For each patient, measurement of pulmonary gas exchange was followed by a series of up to 5 step modifications in the level of ventilator support, with these steps being 50 ml, for volume support, or 2 cm H2O for pressure support.

It is expected that modifications in the level of expression rather than changes in the amino acid sequence of these enzymes are linked to Bti resistance.

PSV is efficient at reducing mechanical ventilation-induced proteolysis and inhibition of protein synthesis without modifications in the level of oxidative injury compared with continuous mechanical ventilation.

Therefore, further direct studies are required to confirm that modifications in the level of expression of GPCRs lead to significant changes in NO/cGMP and other signaling pathways important for γ-globin gene expression in erythroid cells.

To achieve this goal, we used quantitative real-time PCR (qRT-PCR), which is the technique of choice to detect modifications in the level of transcription of specific genes in a reliable and reproducible manner.

To assess whether the rescuing effects of xamoterol on social memory in APP mice is associated with modifications in the level of pCREB, we first measured the level of pCREB in the MeA of APP mice and their WT littermates and found a higher level of pCREB in MeA of APP mice (Fig. S3).

Using an anti-ser 3 p-cofilin antibody, previously reported to allow for detection of subtle changes in cofilin phosphorylation [34], we could not detect significant modifications in the levels of phosphocofilin after mrTIMP-1 treatment either by western blot (Fig. 3E) or by immunofluorescence (results not shown).