Sentence examples for modification in the development from inspiring English sources
Compounds 6a and 6c represent a new structure type for reductive activation and a lead for further modification in the development of better analogues with improved selective toxicity to be used in gene-directed enzyme prodrug therapy.
We have previously reported that ∼25% of human subjects with the sporadic idiopathic interstitial pneumonias have short telomere lengths (<10th percentile) in the absence of telomerase mutations[19], suggesting a role of this epigenetic modification in the development of non-familial pulmonary fibrosis.
The major impacts of genetic modifications in the development of infectious diseases or on the contrary in their eradication are analyzed in this article.
These studies have suggested the role of histone modifications in the development of diabetic retinopathy [ 66].
In this review we consider the role of diverse epigenetic modifications in the development of RA, with a special focus on epigenetic modifications in RASF.
Therefore, the impact of epigenetic modifications in the development of rheumatoid diseases will be exemplified by discussing epigenetic changes in RA by focusing on RA synovial fibroblasts (RASFs).
Bone-derived growth factors and adhesive molecules secreted by tumor cells can cause modifications in the development and progression of metastatic cancer growth.
In this review we draw a detailed picture for the role of diverse epigenetic modifications in the development of RA with a special focus on epigenetic modifications in RASF.
These findings demonstrate the critical role of histone modifications in the development of fibroblast resistance to apoptosis in both a murine model and in patients with pulmonary fibrosis and suggest novel approaches to therapy for progressive fibroproliferative disorders.
Identification of the epigenetic modifications involved in the development and progression of PC will aid in identifying novel therapeutic targets and indicators of biological and diagnostic markers.
Significant difference in methylation levels of a number of genes distinguished tumour tissue samples from their matched normal, demonstrating epigenetic modifications acquired in the development of tumours.
