Sentence examples for modification in target from inspiring English sources

Albeit highly valuable, the models used in those studies were focused on genetic modification in target cells and did not allow for direct testing of the role of non-autonomous factors in the pathogenesis of cancers associated with BRCA1 deficiency.

The results indicate that NT4 peptides are a promising new selective tumor-targeting theranostic for human bladder cancer and may enable personalized oncology in which cancer diagnosis and therapy are obtained by means of the same molecule, with no modification in target binding but by simply "exchanging" the functional units.

By means of this 2 (Group: PG, DG) × 2 (Time: pre-, post-training) factorial design, we tested whether sustained cognitive experience with specific action-related verbs induces congruent brain plasticity modifications in target regions of interest pertaining to the action representation system.

To assess the role of post-translational modifications in target gene choice and activation we investigated the genome-wide level of phosphorylation of Serine 46 of p53 bound to DNA p53-pS466) and of Serine 15 p53-pS155).

This change in fishing strategy implies changes in fishing areas, leading to modifications in target and by-catch species.

An example would be to study changes in adolescent mind wandering after mindfulness training, which would investigate shifts in self-reported mind wandering together with modifications in target detection accuracy and P3b amplitudes reflecting attention efficiency.

The expression information in the present study provides strong support for the suggestion that HD-tuins family HDACs are important in Arabidopsis SE and are more likely to regulate histone modifications in target genes to maintain a high methylation status during SE.

This adaption occurs through a modification in the target's SVM objective function which minimizes the distance of the target's offset from the source's offset.

Of the 37C/D box snoRNAs, 22 had different modification sites in target rRNA or snRNA sequences.

Any modification in these targets could modulate the efficacy of IM and affect its mechanism of action.

30, 31 This reflects the existence of some multifactorial components involving drug sensitivity, acceleration of drug efflux, activation, or inactivation of drugs, modification in drug targets and DNA methylation that contribute to drug resistance property.