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Several studies in wheat and barley support a functional role of promoter histone modification in setting VRN1 expression in the triticea [ 25- 27, 70].
While previous studies in wheat and barley have revealed the functional role of histone modification in setting VRN1 expression, other mechanisms might also be involved.
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If the respective H3K9 modification is involved in setting the exact borders or if the pre-defined borders define H3K9 marks between these limits is currently unknown.
Instead of analysing the correlation of a single gene with the new biological state (GM, GSEAA derives its power from looking at the effect of genetic modification in sets of genes that share a common biological function, cellular localization, chromosomal location or regulation.
The method employs oligonucleotides with desalted purity and no phosphorothioate modification, enabling considerable savings in setting up 96-barcode multiplexing.
Many of these possess histone-modification activity, and are involved in setting up diverse aspects of chromatin organization, highlighting roles for DNA methylation outside of promoter proximal regions 1.
For prize draws we did not find any evidence for effect modification by setting in the regression model (p = 0.15).
In addition, these results may have important clinical implications with regard to life style modification in this setting.
Further study to identify effective parameters and explore the role of team leaders for sustained behavior modification in our setting is being undertaken.
A 6-month period (as used in previous studies [ 4]) was chosen because the high visit rate of diabetic patients within KPNC and the use of primary care teams who can reach out to initiate therapy modification on the physician's behalf via phone or mail give sufficient opportunity for therapy modification in this setting.
In addition, the number of hits for this modification was set in relation to the overall number of peptide hits within the peptide under investigation.
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