Sentence examples for modification in promoters of from inspiring English sources
Chronic alcohol abuse in humans can result in global and gene-specific increases in H3K4me3 in the brain cortex (Ponomarev et al. 2012) and in either increases or decreases of this modification in promoters of specific genes in the hippocampus (Zhou et al. 2011).
Thus, the density of H3K27me3 modification in the promoters of genes was strongly stratified, and it discriminated between two specific classes of gene functions.
For the foetal samples, there was a decreased level of H3K27me3 modification in the promoters of the high and medium gene expression categories compared with non‐expressed genes (P = 8.2E‐15, P = 2.5E‐3 respectively; Behrens Fischer test).
In order to characterize the regulation of GABARAP gene family expression in cancer cells, we analyzed their expression and the epigenetic modifications in the promoters of these genes in in vitro human BC cell models.
To investigate whether the synergistic re-expression of aberrantly silenced genes was linked to LSD1 inhibition and changes in chromatin that favour transcription, the levels of various histone modifications in the promoter of SFRP2 were examined in HCT116 cells.
To explore how histone modifications in the promoter of Nkx2.5 are associated with its expression, we examined histone H3 Lys4 trimethylation (H3K4me3), a prominent active histone mark associated with active genes.
We could not find chromatin modification in the promoter regions of the X chromosome genes RGAG1 and CHRDL1 nor for the GALR1 gene.
We also examined histone modification in the promoter region of miR-17-92 miR-17-92 miR-17-92
To assess the importance of each modification in classifying promoters and enhancers, we constructed classifiers using each mark individually.
To examine whether the sequence specificities differ between promoters and non-promoter regions, we calculated sequence specificities of histone modifications in the promoters and non-promoter regions.
To examine if there are any tight links between any of the four clusters of genes and the status of histone modification in each promoter is also interesting.
