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We also discuss the biological consequences of cholesterol modification, in particular the use of cholesterol as a molecular handle in the spatial deployment of the protein signal in developing tissues.
One is based on the material pore structure modification, in particular on the presence of big enough interconnected pores and channels.
In the next section, the reduction of these bubble parameters is shown to be a result of the surface modification, in particular the increased surface wettability, found for the nanofluid-boiled surfaces.
RNAi guides histone modification, in particular methylation of H3 at lysine 9 (H3K9me2) which is characteristic for heterochromatin, via an interaction between complexes containing small interfering RNAs (siRNAs) and nascent transcripts at the locus [12].
Ling and hake may also be unequally affected by ecosystem fluctuations or modification, in particular, the benthic foraging of ling makes it potentially vulnerable to any negative impacts of bottom trawling on benthic fauna.
One of the most oncogenic miRNAs, miR-21 [12], has been shown to be involved in invasion and metastasis in many cancer types by its action on numerous genes involved in extracellular matrix modification, in particular PTEN (reviewed in [13]), a tumor suppressor gene involved in melanoma etiology [14].
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We are also evaluating the role of epigenetic modifications, in particular DNA methylation, as potential mediators of the health effects of metals.
Although in the recent years much progress has been made in identifying readers of histone modifications, in particular methylation, recognition of the majority of known histone marks is still poorly understood.
In response to cellular requirements, USP25 would undergo several modifications, in particular, monoubiquitination at K99 or sumoylation at the same residue (Figure 6A).
The reviewers therefore find that with some modifications, in particular to the discussion, this paper should be suitable for eLife.
Research in epigenetics originally focused on DNA modifications, in particular methylation, which was first suggested in 1969 to play a defining role in long-term memory.
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