Exact(2)
Our observation of preferential enrichment of the H3K9me3 marker along the same phased haplotype in this study is therefore in broad agreement with the observed parent-of-origin chromosome bias of this modification in mice.
Interestingly, in this proposed scoring system, 'starting evidence', which includes data from in vitro research, genetic modification in mice, and preclinical animal models of disease, only contributes a maximum of up to 11%% of the total translatability score.
Similar(58)
The researchers validated their findings by using their antibody, which can specifically detect this protein modification in mouse models.
Furthermore, increasing IKr by overexpression of hERG currents, either by adenoviral transfer in the rabbit or guinea pig or by transgenic modification in mouse was reported to shorten APD (Nuss et al., 1999; Royer et al., 2005).
He won the Nobel Prize in Physiology or Medicine in 2007 for his contribution to the discovery of principles for introducing specific gene modifications in mice by the use of embryonic stem cells.
In recognition of their discovery of how homologous recombination can be used to introduce genetic modifications in mice through embryonic stem cells, Mario Capecchi, Martin Evans and Oliver Smithies were awarded the 2007 Nobel Prize for Physiology or Medicine.
In 2007 Capecchi, Evans and Smithies received the Nobel Prize 'for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells'; they used homologous recombination in embryonic stem cells [ 66].
In general, these models were created by introducing genetic modifications in mice that resemble the genetic defects of IBD patients, or by relying on external disturbances to induce disease.
To our knowledge, no studies have evaluated whether high-fat diet/obesity offsets the protective effect of other genetic modifications in mice such as ablation of Adamts5 or Mmp13.
Not only is genetic modification easier in mice, but it is likely to become much more feasible in a wide range of other species, including pigs, fish, monkeys, and even humans.
The lack of spiral arteriole modification observed in mice deficient in uNK cells further supports this hypothesis (Greenwood et al., 2000; Ashkar et al., 2003).
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