Sentence examples for modification in mammals from inspiring English sources
Bachman, M. et al. 5-Formylcytosine can be a stable DNA modification in mammals.
N6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification in mammals.
CpG methylation is the major covalent DNA modification in mammals and is another important epigenetic mechanism.
DNA methylation is a well-characterized form of epigenetic modification in mammals, and methylation of CpG sites in the promoter regions of genes can critically affect transcriptional regulation [10].
DNA methylation is perhaps the most extensively studied epigenetic modification in mammals.
Most DNA modification in mammals is the methylation of cytosine (5mC) in the context of the CG dinucleotide [ 1– 3].
DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
Our knowledge about the genome-wide distribution of DNA methylation, how it changes during cellular differentiation and how it relates to histone methylation and other chromatin modifications in mammals remains limited.
In addition, we have shown a lower number of C/D snoRNA genes guiding rRNA modifications in mammals relative to other vertebrate classes [ 16].
Pinpointing a cellular phenotype to histone modifications in mammals is not straightforward, because amino acid substitutions cannot be applied by genetic approaches and also because the enzymes catalyzing modifications often modify multiple proteins.
Elimination of β1,2-xylose and core α1,3-fucose not only demonstrated the ability of plants to synthesize human-type structures without showing any obvious phenotype but also permitted the generation of GnGn, the substrate for further modifications in mammals, such as galactosylation, sialylation, branching, introduction of a bisecting GlcNAc or fucosylation (Figs. 1 and 2).
