Glycosylation is a highly dynamic posttranslational modification resulting in distinct glycan patterns generated across different tissues, and even developmental or disease stages.
Interestingly, our results demonstrate that Rsc3 and Rsc30 regulate the associated modification cohort in distinct ways (positive and negative regulation, respectively, Figure 2A, B), consistent with experimental evidence that they have different roles in regulation, although they interact physically [ 17].
Moreover, either ischemia/reperfusion injury itself or protein binding uremic toxin can leads to epigenetic modifications resulting in distinct genomic signatures [ 36, 65, 66].
Previously, we have shown that PC346DCC, PC346Flu1 and PC346Flu2 display different AR modifications that resulted in distinct mechanisms of hormone-therapy refractory growth [20].
Recently, a "histone code" hypothesis has been proposed to explain how different histone modifications can result in distinct chromatin-regulated functions [5], [6].
These and other histone modifications are distributed in distinct patterns in the genome and variably associated with gene expression levels [ 22, 40- 49].
These preliminary data suggest that the additional evolutionary modifications have occurred in distinct levels in the enzymes maintained after the loss of biosynthetic capability.
Since NRP1S612A did not inhibit p130Cas phosphorylation, we conclude that the role of NRP1 CS-GAG modification in migration is distinct from the role of NRP1 in PDGF signalling.
The methyl modifications on H3K9 exist in distinct mono-, di-, and tri-methyl states (H3K9me1, H3K9me2, and H3K9me3, respectively), with each responsible for governing distinct cellular functions.
In the case of imprinted genes, two alleles with parental-specific epigenetic modifications coexist and result in distinct allelic expression patterns.
