Sentence examples for modification in development from inspiring English sources
Similar to chromatin modifications, DNA methylation has to be understood as a dynamic and reversible modification in development.
In agreement with this, an increasingly large amount of experimental data shows the relevance of chromatin modifications in development [ 5], disease [ 6], etc.
Treatment of E. invadens trophozoites with TSA or SCFAs blocks their in vitro development to the cyst stage, suggesting a biological role for histone modification in Entamoeba development [ 23].
Histone acetylation is a significant epigenetic modification in embryo development and nuclear reprogramming.
Compounds 6a and 6c represent a new structure type for reductive activation and a lead for further modification in the development of better analogues with improved selective toxicity to be used in gene-directed enzyme prodrug therapy.
We identified the DP1 gene by map-based cloning and found it encodes a nuclear-localized AT-hook DNA binding protein, suggesting a grass-specific role of chromatin architecture modification in flower development.
This factor has a core interaction motif required for H3/H4 heterodimerization [19], which suggests regional epigenetic modification in early development.
We have previously reported that ∼25% of human subjects with the sporadic idiopathic interstitial pneumonias have short telomere lengths (<10th percentile) in the absence of telomerase mutations[19], suggesting a role of this epigenetic modification in the development of non-familial pulmonary fibrosis.
Consistent with a modification in senescence development, differences were found in cell-cycle distribution in miR-300-expressing miR-300-expressing miR-300-expressing
One interesting question is the role of epigenetic modification in oligometastasis development given the known role of DNA methylation in maintenance of the imprinted status of 14q32.
Alternatively, while zebrafish that lack norepinephrine are healthy, mice containing this modification die early in development.
