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In this paper we present a simple way to construct multistep codes specially designed for the numerical integration of oscillatory problems introducing a simple modification in classical multistep methods.
In order to avoid sub-therapeutic plasma drug concentrations a modification in classical pharmacokinetic model is proposed and discussed through theoretical calculations for different hypothetical pharmacokinetic situations and a practical single dose pharmacokinetic study with a first order kinetic CRDDS for nifedipine (a short half-life drug; about 2 h).
Platelet aggregation was measured using a 96-well plate modification in classical light transmission aggregometry developed in our laboratory 11.
Platelet aggregation in response to incremental concentrations of five agonists was measured using a 96-well plate modification in classical light transmission aggregometry, as previously described 11.
Agonist-induced platelet aggregation in patients with metastatic cancer and healthy controls was measured using a 96-well platelet modification in classical light transmission aggregometry.
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It is shown that improved therapeutic efficacy could be expected from a CRDDS developed based on proposed modification in the classical pharmacokinetic model.
The modifications of body posture in classical dance had implications on the average aesthetic response of our contemporary non-expert participants.
Such modification reduces the well-known chattering problem in classical sliding mode control.
Cell migration was assessed in classical wound healing assays with some modifications (Rodriguez et al., 2005).
Some of the weapons of antiquity disappeared as practical military implements in classical and medieval times, and all underwent modification, but, with the exception of the halberd and crossbow, virtually every significant pre-gunpowder weapon was known in antiquity.
A recent generalization of Theorem A is proved in [3] using the following modification of classical Carathéodory's convex hull theorem.
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