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Crosio, C., Cermakian, N., Allis, C. D. & Sassone-Corsi, P. Light induces chromatin modification in cells of the mammalian circadian clock.
In view of the OGT and OGA are the only enzymes that involved in O-GlcNAc post-translational modification in cells, it is not difficult to understand that both enzymes are essential to cell growth, ontogeny, and survival in mammals.
Protein glycosylation is a ubiquitous post-translational modification in cells.
To test if activation of DNA damage checkpoint is required for UV-induced Rpb1 sumoylation, we examined the modification in cells lacking Mec1, which plays a key role in activation of checkpoint in response to UV DNA damage [2].
However, a major barrier for clear understanding of the role of Shh cholesterylation has been lack of appropriate tools to study the modification in cells.
Although the limited resolution of confocal microscopy prevents direct detection of covalent ShhN modification in cells, these data are consistent with the degree and specificity of labelling observed by in-gel fluorescence.
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It is widely recognized that microgravity exposition lead to impressive modification in cell cycle distribution [ 14].
Phosphorylation is the most widespread post-translational protein modification in cell signaling [ 17].
All experiments evidenced major modification in cell structure and in cell growth features after cell exposure to AZD1152-HQPA.
In the present study, we did not observe modification in cell motility or invasiveness of MT2A-overexpressing cells or MT2A-silenced cells compared with osteosarcoma parental cells.
Consequently, the enzymes that bring about protein phosphorylation (most widely occurring post-translational modification) in cell, the kinases, have thus emerged as propitious therapeutic targets in cancers.
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