The authors observed epigenetic modifications in a number of genes, with alterations observed in CpG methylation (PPARγ, PPARα and TGF-β 1), histone H3 acetylation (PPARγ and TGF-β 1) and other chromatin modifications (PPARγ).
In addition, the generality of the solid-phase synthetic methodology should facilitate the construction of other sulfopeptide and sulfoprotein libraries to interrogate the importance of Tyr sulfate modifications in a number of diverse systems, including chemokine-chemokine receptor interactions (e.g. CCR5/RANTES), decoy receptors, and complement proteins, in the future.
The problem is especially demanding because of the almost symmetric structure of the tailcone, which in its initial configuration (prior to modification) results in a number of very weakly excited responses to certain excitations, so the corresponding terms in the full 6×6 receptance matrix are very difficult to obtain.
Western blotting is currently the only method available for monitoring PCNA ubiquitination and is, by its very nature, rather crude as it only provides an indication of the average level of the modification in a large number of cells.
During knowledge acquisition, given a case x that requires an NRDR knowledge base to be modified, the modification can occur in a number of places.
Protein glycosylation, as an important post-translational modification, is implicated in a number of ailments.
Our pathway ontology analysis revealed that the differentially expressed genes that were regulated by changes of H3K9Ac and/or H3K9Me2 modifications were involved in a number of cellular pathways.
Epigenomic features, such as DNA methylation and histone modifications, are involved in a number of key cellular processes ranging from the regulation of gene expression (Li and Reinberg 2011), to splicing (Shukla et al. 2011) and the repression of transposable elements (Miura et al. 2001).
Treatment of TNH with PGO leads to modification of a number of Arg residues in TNH.
Although improving P use efficiency via transgenic modification has been reported in a number of crops (Ramaekers et al., 2010; Tian et al., 2012), studies of transgenic wheat with improved P use efficiency are still lacking.
