Sentence examples for modification have targeted from inspiring English sources
Up until recently few studies on attention bias modification have targeted clinical populations of people suffering from social anxiety.
The method described here has enabled highly efficient modification of every gene we have targeted, including a number for which previously published strategies have been unsuccessful.
In these engineered plants, which have targeted metabolic pathway modifications, various unintended physiological, biochemical, and cellular changes have occurred [ 12- 14].
Still, aberrant modifications are observed in diseased cells, and the enzymes that regulate histone modification have become important targets in drug development programs.
Advancements in research techniques in α-synuclein targeted disease modification have utilised methods such as viral mediated expression of human α-synuclein, as well as the inoculation of pathogenic α-synuclein species from Lewy Bodies of PD patients, for accurately modelling progressive self-propagating neurodegeneration.
More recently, the emergence of genome editing technologies enabling direct and precise genome modification have allowed gene replacement or target-specific gene insertion via homologous recombination, and site-specific gene deletion or insertion via non-homologous end joining on the target of interest by using custom engineered nucleases15.
Attempts at modification have failed.
For a long time, targeted genome modification has been heavily relied on large-scale traditional forward genetic screens, such as ENU (N-ethyl-N-nitrosourea) mutagenesis derived TILLING (Targeting Induced Local Lesions IN Genomes) strategy and pseudo-typed retrovirus mediated insertional mutagenesis.
Future studies will be required to establish the effects that O-GlcNAc modifications have on the target proteins that were identified in this study, and the functional significance of the modifications on specific insulin pathway outcomes.
