Although the exact pathways mediate by these genes are still unclear, one might speculate that these OsWD40 genes play important roles in histone modification.
MT genes play a crucial role in many solid tumours and the importance of epigenetic modifications of MT genes should be more analysed.
In agreement with ABC model, loss of C function or expression modifications of the C function genes played a central role in the production of excessive numbers of petals.
Epigenetic modifications of genes also play a key role in the malignant transformation of glioma cells.
Besides RA, there is increasing evidence that histone modifications of certain genes might play a role in the pathogenesis of SSc.
- The availability of these resources prompted a series of follow-up studies that expanded the arsenal of computational tools in bioinformatics and shed light on the roles that histone modifications may play in gene transcription.
It is tempting to postulate that these modifications (F or HN genes) may play a role in virulence or emergence of escape mutants and finally the apparent lack of vaccine efficacy observed in the field.
Figure 6 shows that these preserved intramodular hub genes are significantly enriched for genes that play a role in infectious disease and infection mechanism, post-translational modification and RNA post-transcriptional modification.
In addition, some genes involved in cell wall modification play an important role in basal disease resistance (An et al. [2008]).
