As mentioned above, genes belong to one modification cohort if they display significantly high levels of the corresponding modification at promoters.
Genes belong to one modification cohort if they display significantly high levels (Z score > 1.64, P value < 0.05) of the corresponding modification at promoters (see Additional file 1).
Among the functional group of 'protein modification' the majority of up-regulated genes belong to the core oligosaccharide synthesis (DPM1, DIE2), oligosaccharyltransferase complex (OST1, OST2, OST3, SWP1, STT3, WBP1 ), glycoprotein processing (ALG2, ALG7, SEC53), GPI anchor biosynthesis (GPI2, GPI14, PSA1) and Golgi/O-linked glycosylation (PMT1, PMT2, PMT4, PMT6).
Other relevant genes belong to several different groups: those for ribosome biogenesis; chromatin modification; the genome stability; and cell proliferation.
These genes belong to apoptosis, metabolism, cell cycle, tumor growth and suppressor genes.
These genes belong to the anti-apoptotic gene sub-family, Bcl-2.
All these genes belong to Group II.
Other genes belong to various antioxidant systems.
These genes belong to several functional categories.
Among them, 79 genes belong to Group I and 219 genes belong to Group II.
